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cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein.

Identifieur interne : 001A93 ( Main/Exploration ); précédent : 001A92; suivant : 001A94

cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein.

Auteurs : K A Cimprich [États-Unis] ; T B Shin ; C T Keith ; S L Schreiber

Source :

RBID : pubmed:8610130

Descripteurs français

English descriptors

Abstract

A family of proteins involved in cell cycle progression, DNA recombination, and the detection of DNA damage has been recently identified. One of the members of this family, human ATM, is defective in the cells of patients with ataxia telangiectasia and is involved in detection and response of cells to damaged DNA. Other members include Mei-41 (Drosophila melanogaster), Mec1p (Saccharomyces cerevisiae), and Rad3 (Schizosaccharomyces pombe), which are required for the S and G2/M checkpoints, as well as FRAP (Homo sapiens) and Torl/2p (S. cerevisiae), which are involved in a rapamycin-sensitive pathway leading to G1 cell cycle progression. We report here the cloning of a human cDNA encoding a protein with significant homology to members of this family. Three overlapping clones isolated from a Jurkat T-cell cDNA library revealed a 7.9-kb open reading frame encoding a protein that we have named FRP1 (FRAP-related protein) with 2644 amino acids and a predicted molecular mass of 301 kDa. Using fluorescence in situ hybridization and a full-length cDNA FRP1 clone, the FRP1 gene has been mapped to the chromosomal locus 3q22-q24. FRP1 is most closely related to three of the PIK-related kinase family members involved in checkpoint function--Mei-41, Mec1p, and Rad3--and as such may be the functional human counterpart of these proteins.

DOI: 10.1073/pnas.93.7.2850
PubMed: 8610130
PubMed Central: PMC39722


Affiliations:


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Le document en format XML

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<term>Animals (MeSH)</term>
<term>Ataxia Telangiectasia (genetics)</term>
<term>Ataxia Telangiectasia Mutated Proteins (MeSH)</term>
<term>Base Sequence (MeSH)</term>
<term>Cell Cycle (genetics)</term>
<term>Cell Cycle Proteins (biosynthesis)</term>
<term>Cell Cycle Proteins (chemistry)</term>
<term>Cell Cycle Proteins (genetics)</term>
<term>Cell Line (MeSH)</term>
<term>Chromosome Mapping (MeSH)</term>
<term>Chromosomes, Human, Pair 3 (MeSH)</term>
<term>Cloning, Molecular (MeSH)</term>
<term>Conserved Sequence (MeSH)</term>
<term>DNA Damage (MeSH)</term>
<term>DNA Primers (MeSH)</term>
<term>DNA, Complementary (MeSH)</term>
<term>Drosophila melanogaster (genetics)</term>
<term>Female (MeSH)</term>
<term>Fungal Proteins (biosynthesis)</term>
<term>Fungal Proteins (chemistry)</term>
<term>Fungal Proteins (genetics)</term>
<term>Gene Library (MeSH)</term>
<term>Humans (MeSH)</term>
<term>In Situ Hybridization, Fluorescence (MeSH)</term>
<term>Karyotyping (MeSH)</term>
<term>Male (MeSH)</term>
<term>Molecular Sequence Data (MeSH)</term>
<term>Organ Specificity (MeSH)</term>
<term>Phylogeny (MeSH)</term>
<term>Pregnancy (MeSH)</term>
<term>Protein Kinases (biosynthesis)</term>
<term>Protein Kinases (chemistry)</term>
<term>Protein Kinases (genetics)</term>
<term>Protein-Serine-Threonine Kinases (MeSH)</term>
<term>Recombination, Genetic (MeSH)</term>
<term>Restriction Mapping (MeSH)</term>
<term>Saccharomyces cerevisiae (genetics)</term>
<term>Schizosaccharomyces (genetics)</term>
<term>Sequence Homology, Amino Acid (MeSH)</term>
<term>T-Lymphocytes (MeSH)</term>
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<term>Altération de l'ADN (MeSH)</term>
<term>Amorces ADN (MeSH)</term>
<term>Animaux (MeSH)</term>
<term>Ataxie-télangiectasie (génétique)</term>
<term>Banque de gènes (MeSH)</term>
<term>Cartographie chromosomique (MeSH)</term>
<term>Cartographie de restriction (MeSH)</term>
<term>Caryotypage (MeSH)</term>
<term>Chromosomes humains de la paire 3 (MeSH)</term>
<term>Clonage moléculaire (MeSH)</term>
<term>Cycle cellulaire (génétique)</term>
<term>Données de séquences moléculaires (MeSH)</term>
<term>Drosophila melanogaster (génétique)</term>
<term>Femelle (MeSH)</term>
<term>Grossesse (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Hybridation fluorescente in situ (MeSH)</term>
<term>Lignée cellulaire (MeSH)</term>
<term>Lymphocytes T (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Phylogenèse (MeSH)</term>
<term>Protein kinases (biosynthèse)</term>
<term>Protein kinases (composition chimique)</term>
<term>Protein kinases (génétique)</term>
<term>Protein-Serine-Threonine Kinases (MeSH)</term>
<term>Protéines du cycle cellulaire (biosynthèse)</term>
<term>Protéines du cycle cellulaire (composition chimique)</term>
<term>Protéines du cycle cellulaire (génétique)</term>
<term>Protéines fongiques (biosynthèse)</term>
<term>Protéines fongiques (composition chimique)</term>
<term>Protéines fongiques (génétique)</term>
<term>Protéines mutées dans l'ataxie-télangiectasie (MeSH)</term>
<term>Recombinaison génétique (MeSH)</term>
<term>Saccharomyces cerevisiae (génétique)</term>
<term>Schizosaccharomyces (génétique)</term>
<term>Similitude de séquences d'acides aminés (MeSH)</term>
<term>Spécificité d'organe (MeSH)</term>
<term>Séquence conservée (MeSH)</term>
<term>Séquence d'acides aminés (MeSH)</term>
<term>Séquence nucléotidique (MeSH)</term>
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<term>Fungal Proteins</term>
<term>Protein Kinases</term>
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<term>Fungal Proteins</term>
<term>Protein Kinases</term>
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<term>Fungal Proteins</term>
<term>Protein Kinases</term>
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<term>DNA, Complementary</term>
<term>Protein-Serine-Threonine Kinases</term>
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<term>Protein kinases</term>
<term>Protéines du cycle cellulaire</term>
<term>Protéines fongiques</term>
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<term>Drosophila melanogaster</term>
<term>Protein kinases</term>
<term>Protéines du cycle cellulaire</term>
<term>Protéines fongiques</term>
<term>Saccharomyces cerevisiae</term>
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<term>Animals</term>
<term>Base Sequence</term>
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<term>Conserved Sequence</term>
<term>DNA Damage</term>
<term>Female</term>
<term>Gene Library</term>
<term>Humans</term>
<term>In Situ Hybridization, Fluorescence</term>
<term>Karyotyping</term>
<term>Male</term>
<term>Molecular Sequence Data</term>
<term>Organ Specificity</term>
<term>Phylogeny</term>
<term>Pregnancy</term>
<term>Recombination, Genetic</term>
<term>Restriction Mapping</term>
<term>Sequence Homology, Amino Acid</term>
<term>T-Lymphocytes</term>
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<term>Altération de l'ADN</term>
<term>Amorces ADN</term>
<term>Animaux</term>
<term>Banque de gènes</term>
<term>Cartographie chromosomique</term>
<term>Cartographie de restriction</term>
<term>Caryotypage</term>
<term>Chromosomes humains de la paire 3</term>
<term>Clonage moléculaire</term>
<term>Données de séquences moléculaires</term>
<term>Femelle</term>
<term>Grossesse</term>
<term>Humains</term>
<term>Hybridation fluorescente in situ</term>
<term>Lignée cellulaire</term>
<term>Lymphocytes T</term>
<term>Mâle</term>
<term>Phylogenèse</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Protéines mutées dans l'ataxie-télangiectasie</term>
<term>Recombinaison génétique</term>
<term>Similitude de séquences d'acides aminés</term>
<term>Spécificité d'organe</term>
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<term>Séquence d'acides aminés</term>
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<div type="abstract" xml:lang="en">A family of proteins involved in cell cycle progression, DNA recombination, and the detection of DNA damage has been recently identified. One of the members of this family, human ATM, is defective in the cells of patients with ataxia telangiectasia and is involved in detection and response of cells to damaged DNA. Other members include Mei-41 (Drosophila melanogaster), Mec1p (Saccharomyces cerevisiae), and Rad3 (Schizosaccharomyces pombe), which are required for the S and G2/M checkpoints, as well as FRAP (Homo sapiens) and Torl/2p (S. cerevisiae), which are involved in a rapamycin-sensitive pathway leading to G1 cell cycle progression. We report here the cloning of a human cDNA encoding a protein with significant homology to members of this family. Three overlapping clones isolated from a Jurkat T-cell cDNA library revealed a 7.9-kb open reading frame encoding a protein that we have named FRP1 (FRAP-related protein) with 2644 amino acids and a predicted molecular mass of 301 kDa. Using fluorescence in situ hybridization and a full-length cDNA FRP1 clone, the FRP1 gene has been mapped to the chromosomal locus 3q22-q24. FRP1 is most closely related to three of the PIK-related kinase family members involved in checkpoint function--Mei-41, Mec1p, and Rad3--and as such may be the functional human counterpart of these proteins.</div>
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<AbstractText>A family of proteins involved in cell cycle progression, DNA recombination, and the detection of DNA damage has been recently identified. One of the members of this family, human ATM, is defective in the cells of patients with ataxia telangiectasia and is involved in detection and response of cells to damaged DNA. Other members include Mei-41 (Drosophila melanogaster), Mec1p (Saccharomyces cerevisiae), and Rad3 (Schizosaccharomyces pombe), which are required for the S and G2/M checkpoints, as well as FRAP (Homo sapiens) and Torl/2p (S. cerevisiae), which are involved in a rapamycin-sensitive pathway leading to G1 cell cycle progression. We report here the cloning of a human cDNA encoding a protein with significant homology to members of this family. Three overlapping clones isolated from a Jurkat T-cell cDNA library revealed a 7.9-kb open reading frame encoding a protein that we have named FRP1 (FRAP-related protein) with 2644 amino acids and a predicted molecular mass of 301 kDa. Using fluorescence in situ hybridization and a full-length cDNA FRP1 clone, the FRP1 gene has been mapped to the chromosomal locus 3q22-q24. FRP1 is most closely related to three of the PIK-related kinase family members involved in checkpoint function--Mei-41, Mec1p, and Rad3--and as such may be the functional human counterpart of these proteins.</AbstractText>
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